abstract：:High-risk (HR) acute lymphoblastic leukemia (ALL) remains one of the greatest challenges in pediatric oncology. Relapsed ALL is a leading cause of death in young people, and further improvements in outcome will required the development of therapeutic approaches directed against rational therapeutic targets, as escalat...

journal_title：Pediatric blood & cancer

authors： Hunger SP,Raetz EA,Loh ML,Mullighan CG

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Children with sickle cell disease (SCD) and abnormal transcranial Doppler (TCD) ultrasonography have a high risk of stroke, but this risk is greatly reduced when chronic transfusion therapy is administered. The change in TCD velocities during chronic transfusion therapy and rate and frequency of normalizatio...

journal_title：Pediatric blood & cancer

authors： Kwiatkowski JL,Yim E,Miller S,Adams RJ,STOP 2 Study Investigators.

更新日期：2011-05-01 00:00:00

abstract：:To assess safety and tolerability, we administered valacyclovir, an oral anti-viral medication that inhibits erythrocyte sickling in vitro, to 14 subjects with sickle-cell anemia for 1 week at a standard dose of 1,000 mg every 8 hr. No clinically significant adverse effects occurred. In 11 subjects in steady state, th...

journal_title：Pediatric blood & cancer

authors： Ender KL,DeBellis RH,Erlanger BF,Billote GB,Brittenham GM

更新日期：2011-05-01 00:00:00

abstract：:Juvenile xanthogranuloma (JXG) is a disorder of disputed origin thought to be related to the dermal/interstitial macrophage. A 5-year-old female presented with an aggressive systemic JXG that developed 5 months after the diagnosis of T-cell acute lymphoblastic leukemia (T-ALL). Examination of the T-cell receptor gamma...

journal_title：Pediatric blood & cancer

authors： Perez-Becker R,Szczepanowski M,Leuschner I,Janka G,Gokel M,Imschweiler T,Völpel S,Niehues T,Klapper W

更新日期：2011-05-01 00:00:00

abstract：:We report a novel glucose-6-phosphate dehydrogenase (G6PD) mutation, which we propose to name G6PD Cincinnati (c.1037A > T, p.N346I), found in combination with G6PD Gastonia (c.637G > T, p.V213L) in an infant who presented with neonatal cholestasis. The G6PD Cincinnati mutation results in a non-conservative amino acid...

journal_title：Pediatric blood & cancer

authors： Mizukawa B,George A,Pushkaran S,Weckbach L,Kalinyak K,Heubi JE,Kalfa TA

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:The aims of this study were to define the mRNA expression profiles of MYCN, DDX1, TrkA, and TrkC in biopsy tumor samples from 64 Brazilian patients with neuroblastomas of different risk stages and to correlate altered expression with prognostic values. PROCEDURE:Patients were retrospectively classified into...

journal_title：Pediatric blood & cancer

authors： de Souza DR,Sanabani SS,de Souza AC,Filho Odone V,Epelman S,Bendit I

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:An adapted LMB 96 derived protocol for B-cell non-Hodgkin lymphoma (NHL) was implemented at the pediatric oncology unit of the Children Welfare Teaching Hospital in Baghdad (Iraq) from 2000 to present. The purpose was to evaluate the feasibility and efficacy of this intensive therapeutic regimen in a limited...

journal_title：Pediatric blood & cancer

authors： Moleti ML,Al-Hadad SA,Al-Jadiry MF,Al-Darraji AF,Al-Saeed RM,De Vellis A,Piciocchi A,Uccini S,Foà R,Testi AM

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Anthracycline cardiomyopathy is of concern in children treated for acute myeloid leukaemia (AML), but there are few data on the incidence and natural history of cardiotoxicity after AML treatment in the United Kingdom, where regimens have included high anthracycline exposure. PROCEDURE:Prevalence and predic...

journal_title：Pediatric blood & cancer

authors： Temming P,Qureshi A,Hardt J,Leiper AD,Levitt G,Ancliff PJ,Webb DK

更新日期：2011-04-01 00:00:00

abstract：:Deferasirox (Exjade®, Novartis) is a widely used oral iron chelator for the treatment of patients with iron overload due to chronic transfusion therapy for diseases such as β-thalassemia and sickle cell disease. Renal side effects of deferasirox are common and include non-progressive increases in serum creatinine, how...

journal_title：Pediatric blood & cancer

authors： Rheault MN,Bechtel H,Neglia JP,Kashtan CE

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Acute and chronic clinical manifestations of sickle-cell disease (SCD) lead to significant healthcare utilization, especially of the emergency department (ED). Limited population-level data are available in SCD with the ability to connect patients to visits, leaving us with minimal description of utilization...

journal_title：Pediatric blood & cancer

authors： Wolfson JA,Schrager SM,Coates TD,Kipke MD

更新日期：2011-03-01 00:00:00

abstract：:Acute bilineal leukemias are rare and are commonly associated with t(9;22) and MLL abnormalities. Herein, we report a pediatric case of bilineal T/myeloid acute leukemia associated with del (9q)(q13q22) and TLX3/BCL11B fusion due to the cryptic t(5;14)(q35;32). FISH studies confirmed the TLX3/BCL11B fusion in both the...

journal_title：Pediatric blood & cancer

authors： Oliveira JL,Kumar R,Khan SP,Law ME,Erickson-Johnson M,Oliveira AM,Ketterling RP,Dogan A

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Despite the presence of reports on correlation between major congenital defects and cancer, very few studies have investigated the frequency of minor anomalies in childhood malignancy. The aim of this study was to determine the prevalence of minor anomalies in children with hematological malignancy. PROCEDU...

journal_title：Pediatric blood & cancer

authors： Citak FE,Citak EC,Akkaya E,Kosan B,Ezer U,Kurekci AE

更新日期：2011-02-01 00:00:00

abstract：:Two thirds of children with cancer never reach a specialist centre for treatment in South Africa. The majority of those who present have advanced disease. A campaign was undertaken to educate the public and the primary health workers on the Saint Siluan early warning signs of cancer in children. There was a statistica...

journal_title：Pediatric blood & cancer

authors： Poyiadjis S,Wainwright L,Naidu G,Mackinnon D,Poole J

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Posterior fossa syndrome (PFS) is defined as the temporary and complete loss of speech after posterior fossa surgery. The goal of this study was to identify incidence and risk factors for PFS and to determine accompanying neurobehavioral and psychologic problems. PROCEDURE:Between May 2007 and April 2009, c...

journal_title：Pediatric blood & cancer

authors： Küpeli S,Yalçın B,Bilginer B,Akalan N,Haksal P,Büyükpamukçu M

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Premature newborns are vulnerable to iron imbalance, although the iron homeostasis during the perinatal period remains unclear. To clarify the iron metabolism of premature infants, we measured serum prohepcidin concentrations of preterm infants, and analyzed the association with iron parameters. METHODS:Sev...

journal_title：Pediatric blood & cancer

authors： Kitajima J,Ohga S,Kinjo T,Ochiai M,Takahata Y,Honjo S,Hara T

更新日期：2011-02-01 00:00:00

abstract：:Congenital amegakaryocytic thrombocytopenia (CAMT) is a rare autosomal recessive disorder characterized by thrombocytopenia from failure of megakaryopoiesis. CAMT is one of the bone marrow failure syndromes, and the disease progression may involve other lineages leading to pancytopenia. The genetic background of CAMT ...

journal_title：Pediatric blood & cancer

authors： Chung HS,Koh KN,Kim HJ,Kim HJ,Lee KO,Park CJ,Chi HS,Kim SH,Seo JJ,Im HJ

更新日期：2011-02-01 00:00:00

abstract：:This is the case report of a 14-year young female who was diagnosed with solitary bone plasmacytoma (SBP) of proximal tibia and was treated by local involved field radiotherapy. We present the clinical, radiological and pathological findings of the case and review of the available treatment options and prognosis of th...

journal_title：Pediatric blood & cancer

authors： Kumar P,Sharma SC,Saikia UN,Kumar N,Vyas S,Angurana SL

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Resource-rich countries tend to have a higher incidence of childhood acute lymphoblastic leukemia (ALL), whereas lower rates are seen in more deprived countries. This study describes the incidence of childhood acute leukemia in Brazil, an upper middle-income country, based on data from 16 population-based ca...

journal_title：Pediatric blood & cancer

authors： de Souza Reis R Sr,de Camargo B,de Oliveira Santos M,de Oliveira JM,Azevedo Silva F,Pombo-de-Oliveira MS

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Patients with sickle cell disease (SCD) receiving chronic blood transfusions are at risk of developing iron overload and organ toxicity. Chelation therapy with either subcutaneous (SQ) desferrioxamine (DFO) or oral deferasirox is effective in preventing and reducing iron overload but poses significant challe...

journal_title：Pediatric blood & cancer

authors： Kalpatthi R,Peters B,Kane I,Holloman D,Rackoff E,Disco D,Jackson S,Laver JH,Abboud MR

更新日期：2010-12-15 00:00:00

abstract：:Unstable hemoglobin variants represent a rare etiology of congenital hemolytic anemia. Without a high index of suspicion, plus proper laboratory testing and interpretation, the correct diagnosis can be elusive. We report on five children who were initially thought to have other congenital disorders such as hereditary ...

journal_title：Pediatric blood & cancer

authors： Yates AM,Mortier NA,Hyde KS,Hankins JS,Ware RE

更新日期：2010-12-15 00:00:00

abstract：:We report two cases of primary CNS lymphoma (PCNSL) treated with high-dose methotrexate. Though standard adult treatment of PCNSL incorporates whole-brain radiotherapy, the literature suggests it may be possible to delay or avoid radiotherapy and the associated increased risk of neurologic sequelae in pediatric patien...

journal_title：Pediatric blood & cancer

authors： Shah AC,Kelly DR,Nabors LB,Oakes WJ,Hilliard LM,Reddy AT

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Sorafenib is an inhibitor of multiple kinases (e.g., VEGF receptors, PDGFR, FLT3, RET, BRAF, KIT) and is approved by FDA for treatment of two adult cancers. The activity of sorafenib was evaluated against the PPTP's in vitro and in vivo panels. PROCEDURES:Sorafenib was evaluated against the PPTP in vitro pa...

journal_title：Pediatric blood & cancer

authors： Keir ST,Maris JM,Lock R,Kolb EA,Gorlick R,Carol H,Morton CL,Reynolds CP,Kang MH,Watkins A,Houghton PJ,Smith MA

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Little is known about the visual outcome of children affected by an optic pathway glioma (OPG). PROCEDURES:We evaluated the long-term visual outcome of 32 consecutive children affected by OPG without neurofibromatosis type-1 referred to the Pediatric Department of Padua University and managed according to s...

journal_title：Pediatric blood & cancer

authors： Campagna M,Opocher E,Viscardi E,Calderone M,Severino SM,Cermakova I,Perilongo G

更新日期：2010-12-01 00:00:00

abstract：:Treatment with the nucleoside analog cytarabine has been shown to mimic changes in gene expression associated with downregulation of the EWS-FLI1 oncogene in Ewing sarcoma cell lines, selectively inhibit their growth in vitro, and cause tumor regression in athymic nude mice. For this report cytarabine was studied in v...

journal_title：Pediatric blood & cancer

authors： Houghton PJ,Morton CL,Kang M,Reynolds CP,Billups CA,Favours E,Payne-Turner D,Tucker C,Smith MA

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:To analyze the impact of mediastinal irradiation on the incidence of cardiac late effects in long-term survivors of pediatric Hodgkin disease (HD). METHODS:The study cohort comprised 1,132 survivors of HD who received treatment before 18 years of age in consecutive trials between 1978 and 1995. They had mai...

journal_title：Pediatric blood & cancer

authors： Schellong G,Riepenhausen M,Bruch C,Kotthoff S,Vogt J,Bölling T,Dieckmann K,Pötter R,Heinecke A,Brämswig J,Dörffel W

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To assess local control, event-free survival (EFS), and overall survival (OS) rates in 71 patients with localized, completely resected (Group I) alveolar rhabdomyosarcoma (ALV RMS) and their relation to radiation therapy (RT) on IRSG Protocols III and IV, 1984-1997. METHODS:Chart review and standard statistica...

journal_title：Pediatric blood & cancer

authors： Raney RB,Anderson JR,Brown KL,Huh WW,Maurer HM,Meyer WH,Parham DM,Rodeberg DA,Wolden SL,Donaldson SS,Soft-Tissue Sarcoma Committee of the Children's Oncology Group Arcadia California USA.

更新日期：2010-10-01 00:00:00

abstract：:Epidural spinal cord compression as the initial presentation of acute lymphoblastic leukemia (ALL) is a rare and serious complication. Extramedullary disease is rarely reported in patients with ALL. The most common sites are bone, followed by soft tissue, skin and lymph nodes. We describe a child with common B-lineage...

journal_title：Pediatric blood & cancer

authors： Molina B,Lassaletta A,Andion M,Gonzalez-Vicent M,López-Pino MA,Madero L

更新日期：2010-10-01 00:00:00

abstract：:The FIP1L1-PDGFRA fusion gene is the most frequent genetic aberration in myeloid neoplasms associated with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1. Affected patients in adult populations are very sensitive to imatinib therapy. Pediatric cases are rare and so far only one case of FIP1L1-PDGFRA positi...

journal_title：Pediatric blood & cancer

authors： Rathe M,Kristensen TK,Møller MB,Carlsen NL

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Only a few studies have assessed cardiovascular risk factors (CRFs) in childhood cancer survivors. We determined the prevalence of CRFs in long-term survivors of acute lymphoblastic leukemia (ALL) and Wilms tumor. PROCEDURE:Adult survivors of ALL and Wilms tumor treated with radiotherapy and chemotherapy (R...

journal_title：Pediatric blood & cancer

authors： Geenen MM,Bakker PJ,Kremer LC,Kastelein JJ,van Leeuwen FE

更新日期：2010-10-01 00:00:00

abstract：:Anaphylactic/anaphylactoid reaction to methotrexate (MTX) is uncommon. It may occur with the first dose (non-allergic reactions) or after a previous exposure to the drug (allergic or specific reactions). Desensitization has been shown effective in children with allergic-type reactions permitting the continuation of hi...

journal_title：Pediatric blood & cancer

authors： Oulego-Erroz I,Maneiro-Freire M,Bouzón-Alejandro M,Vázquez-Donsión M,Couselo JM

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The presence of central nervous system (CNS) disease in pediatric acute myeloid leukemia (AML) is often thought to confer a worse prognosis. This study examined the outcome of children with AML who had CNS disease at diagnosis. METHODS:Patients enrolled on Children's Cancer Group protocols 2861, 2891, 2941,...

journal_title：Pediatric blood & cancer

authors： Johnston DL,Alonzo TA,Gerbing RB,Lange BJ,Woods WG

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Pediatric health-related quality of life (HRQOL) questionnaires have been validated in children with sickle cell disease (SCD), but small sample sizes in these studies have limited clinical comparisons. We used the baseline clinical data from the Collaborative Data (C-Data) Project of the Comprehensive Sickl...

journal_title：Pediatric blood & cancer

authors： Dampier C,Lieff S,LeBeau P,Rhee S,McMurray M,Rogers Z,Smith-Whitley K,Wang W,Comprehensive Sickle Cell Centers (CSCC) Clinical Trial Consortium (CTC).

更新日期：2010-09-01 00:00:00

abstract：:The objective of this study is to determine the prevalence of adherence to daily medications among children with sickle cell disease (SCD). Prescription records for 12 months were obtained from participants who had insurance in a Medicaid-based single health maintenance organization. Adherence was measured as a ratio ...

journal_title：Pediatric blood & cancer

authors： Patel NG,Lindsey T,Strunk RC,DeBaun MR

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:There is a need for more knowledge about how survivors of childhood cancer perceive their lives and what influence current health status has on their quality of life. The purpose was to describe this among a group of long-term survivors and among a comparison group. PROCEDURE:Telephone interviews were perfo...

journal_title：Pediatric blood & cancer

authors： Sundberg KK,Doukkali E,Lampic C,Eriksson LE,Arvidson J,Wettergren L

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:A total of 201 pediatric cases of acute lymphoblastic leukemia were treated with the ALL-96 protocol by the Kyushu-Yamaguchi Children's Cancer Study Group. PROCEDURE:Risk stratification was based on white cell counts, immunophenotype, the presence of central nervous system disease at diagnosis, organomegaly...

journal_title：Pediatric blood & cancer

authors： Nagatoshi Y,Matsuzaki A,Suminoe A,Inada H,Ueda K,Kawakami K,Yanai F,Nakayama H,Moritake H,Itonaga N,Hotta N,Fujita K,Hidaka Y,Yamanaka T,Kawano Y,Okamura J

更新日期：2010-08-01 00:00:00

abstract：:Hereditary deficiency in human glucose-6-phosphate dehydrogenase (G6PD) is mostly caused by single nucleotide change in the G6PD gene which leads to single amino acid substitution. In 104 cases of Chinese children with G6PD deficiency, RT-PCR-DGGE (denaturing gradient gel electrophoresis) combined with DNA sequencing ...

journal_title：Pediatric blood & cancer

authors： Chen X,Yue L,Li C,Li C

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:A potential long-term complication of central venous catheter (CVC)-related deep vein thrombosis (DVT), both symptomatic and asymptomatic, is development of post-thrombotic syndrome (PTS) characterized by persistent pain, swelling, and skin changes. Signs and symptoms of PTS were reported after CVC removal. ...

journal_title：Pediatric blood & cancer

authors： Revel-Vilk S,Menahem M,Stoffer C,Weintraub M

更新日期：2010-07-15 00:00:00

abstract：BACKGROUND:Carboplatin is the most effective drug in retinoblastoma but systemic clearance is variable in young patients. While most regimens use a flat dose, individualized targeting may provide a more adjusted systemic exposure. PATIENTS AND METHODS:We compared carboplatin doses between two groups of children with r...

journal_title：Pediatric blood & cancer

authors： Allen S,Wilson MW,Watkins A,Billups C,Qaddoumi I,Haik BH,Rodriguez-Galindo C

更新日期：2010-07-15 00:00:00

abstract：BACKGROUND:Although maternal thrombocytopenia during pregnancy is common, its effect on neonatal platelets has not yet been fully evaluated. METHODS:We retrospectively evaluated the rate of thrombocytopenia among 767 healthy term neonates (gestational age 37-42 weeks) born to 723 mothers with pregnancy-induced thrombo...

journal_title：Pediatric blood & cancer

authors： Maayan-Metzger A,Leibovitch L,Schushan-Eisen I,Strauss T,Kenet G,Kuint J

更新日期：2010-07-15 00:00:00

abstract：:Gemtuzumab ozogamicin (GO) is a humanized anti-CD33 antibody used for treating patients with CD33+ acute myeloid leukemia (AML). We report three young children (two infants and one toddler) with AML treated with GO 9 mg/m(2). Two received two doses at diagnosis alone with conventional chemotherapy and one received one...

journal_title：Pediatric blood & cancer

authors： Sayar D,Burstein Y,Bielorai B,Toren A,Dvir R

更新日期：2010-07-15 00:00:00